Influenza A viruses (IAVs), which belong to the family Orthomyxoviridae, are enveloped viruses characterized by segmented genomes consisting of eight single-stranded RNA segments. These viruses are classified into subtypes based on their surface proteins, hemagglutinin (HA) and neuraminidase (NA), with 19 distinct HA and 11 NA antigens giving rise to 209 possible subtypes (e.g., H3N8, H3N1, H5N1, and H7N2). IAVs are globally distributed, exhibit high contagion rates, and continuously evolve, possessing a broad host range that includes various mammals such as horses, dogs, and cats. Understanding the dynamics of host-pathogen interactions and cross-species transmission is critical for effective management. This chapter aims to consolidate current knowledge regarding the equine influenza virus (EIV), canine influenza virus (CIV), and feline influenza virus, addressing aspects of virology, epidemiology, phylogenetics, clinical manifestations, pathology, pathogenesis, diagnosis, prevention and control measures, immunity, zoonotic potential, and future directions for IAV management. While vaccination has been effective in controlling EIV and CIV, outbreaks persist, particularly in regions where herd immunity is compromised. Currently, there are no recognized antiviral treatments, making vaccination crucial for prevention. Notably, there are no commercial vaccines available for feline influenza, and cats are considered potential “mixing vessels” for novel IAVs, which may evolve and adapt through feline hosts before infecting humans. Consequently, enhancing surveillance of feline influenza viruses is essential for the early detection and mitigation of the risks associated with recombinant viruses that could pose a threat to human health.