Very Fast Oscillations, Electrodecrements, and Seizure Initiation (with Comments on pH and Clinical Relevance)

A computer chip must not get too hot, but its operating range of temperatures, perhaps over a range of 50 °C, is far wider than the temperature differences which a brain can tolerate – more in the range of 5 °C. Additionally, with the brain’s cells operating in, and surrounded by, aqueous environments, any number of chemical/biophysical parameters must be tightly controlled. These include concentrations of O2, glucose, ions (Na+, K+, Ca2+, H+ (pH), Mg2+, Cl−, and others), selected amino acids, and neurotransmitters, to name some of them.