Diet-Induced Histone Modifications: Implications for Human Health and Diseases
摘要
Post-translational modifications of histones (PTMs) are key epigenetic regulators and control chromatin-mediated processes such as gene expression, genome organization, DNA replication, and repair and recombination events. Numerous human diseases, including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases (e.g., Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease), have been linked to misregulation of histone modifications. Histone modifications are highly dynamic and respond to various environmental cues, such as diet and dietary compounds, and have been found to alter the epigenome which impacts gene expression. In this chapter, we highlight the role of nutrition-mediated changes in epigenome and its implications for human physiology and health. A better understanding of epigenome modulation by diet may provide new ways of intervention in diseases associated with an epigenetic component and for promoting better health.