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18F-Thymidine

  • Laura Travascio,
  • Federico Padovano,
  • Marzia Colandrea,
  • Mario Leporace,
  • Luca Frontino,
  • Bhagwant Rai Mittal,
  • Ferdinando Calabria,
  • Rakhee Vatsa

摘要

18F-FLT, a thymidine analogue for PET imaging, targets the thymidine salvage pathway, a process by which DNA precursors are supplied to the dividing cells. Clinical indications and a few clinical cases are being illustrated for routine use of 18F-FLT in oncology, after going through synthesis, pharmacokinetics, physiological distribution. PET acquisition protocols are also described.