The chapter presents the daily practices of a company producing pharmaceutical cartons and leaflets. It focuses on the complex design processes of these products that play a significant role for pharmaceutical companies. The contribution starts from the author’s personal experience within a company that produces secondary packaging and package leaflets for pharmaceutical products. In the chapter, the different phases of the decision-making process are presented, following both the technical and relational aspects. In addition to their description, which brings out the complexity of the relationships between companies, the chapter dwells on the issues of innovation and sustainability linked to the design of secondary packaging and package leaflets, which are indispensable today to remain competitive in the market. In this context, the role of new technologies is included, foreshadowing the possible impact on secondary packaging.