Preformulation in Drug Product Design
摘要
This chapter provides an overview of the factors that are considered in dosage form design, including physicochemical properties of drugs, drug solubility and dissolution, drug bioavailability, membrane permeability, and solid-state characteristics. Commonly performed preformulation studies including dissolution testing, x-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, particle size analysis, and drug degradation testing, are discussed.