Gene’s Association with Coronary Stent Stenosis After Drug Eluting Stent: Mini-review

Drug-eluting stents are frequently employed in cardiovascular coronary revascularization procedures, primarily because of their capacity to limit intimal hyperplasia. Stent stenosis has the potential to manifest within the artery that has been treated, which can ultimately result in procedural failure. One potential factor that may contribute to this failure is the genetic composition of the patients. The aim of this study is to investigate the correlation between genetic diversity, as reported in existing literature, and the incidence of coronary revascularization subsequent to angioplasty and the use of drug-eluting stents. Consequently, the involvement of various genetic systems, including antioxidant genes, the inflammatory system, the renin angiotensin system, the anticoagulant system, and the homeostasis system, is assessed in the context of stent restenosis. In conclusion, the utilization of genetic diagnosis for the NOS3, AGT, ACE, and CYP2C19 genes holds promise in improving treatment outcomes through the implementation of personalized interventions to tackle coronary stent restenosis.