The rapid pace of technological change, accelerated by innovations such as artificial intelligence, is reshaping the modern workplace. While these advancements offer significant opportunities for organizational growth, they also present challenges for employee well-being. This entry explores the intersection of leadership, technological change, and employee well-being, highlighting strategies that leaders can employ to manage these transformations effectively. Drawing from transformational, agile, and positive organizational scholarship (POS) leadership frameworks, the entry argues that fostering a supportive work environment is crucial for navigating technological disruptions without compromising employee mental, emotional, and physical health. The job demands-resources (JD-R) model is examined as a tool for balancing increased job demands with essential resources to mitigate burnout and disengagement. By integrating well-being into their leadership approaches, organizations can cultivate resilience and maintain high performance during periods of rapid change. This entry offers insights and practical frameworks for leaders aiming to promote both technological adaptation and employee well-being, demonstrating that these goals are not mutually exclusive but interdependent drivers of sustainable success.