A Novel Poly(3-hexylthiophene) Microelectrode for Ascorbic Acid Monitoring During Brain Cytotoxic Edema
摘要
Neuroelectrochemical sensing technology offers unique benefits for neuroscience research,being able to target measurements of marker changes during physiological or pathological processes. In this paper, we introduce poly(3-hexylthiophene) (P3HT) and nitrogen-doped multiwalled carbon nanotubes (N-MWCNTs) to construct a composite membrane-modified carbon fiber (CF) microelectrode (CFME/P3HT-N-MWCNTs) to detect ascorbic acid (AA). We apply CFME/P3HT-N-MWCNTs to monitor the AA of intercellular fluid, we achieve the observation of the cellular mechanical process of brain cytotoxic edema at the electrochemical level. Our study can apply a new in vivo electrochemical sensing technology to construct in vivo implanted microelectrodes and monitor key biomarkers. Thanks to this research approach, we will explore the molecular basis of biomechanic-related diseases and discover some underlying mechanisms.