Micromechanical Properties Investigation of Rabbit Carotid Aneurysms by Atomic Force Microscopy

The lack of research on the micromechanical properties of cerebral aneurysms limits observing the mechanism of aneurysm rupture. The aim of this biomechanical study is to explore the differences in micromechanical properties between the fusiform aneurysm and the healthy artery. Rabbit models were used to study the hemodynamics of intracranial aneurysms. Atomic force microscopy (AFM) was applied to press the media and adventitia in between aneurysm and healthy arteries. The elasticity modulus for vascular middle and adventitia in aneurysm were larger than those in healthy arteries. This study provides valuable data for understanding the micromechanical properties of the fusiform aneurysm.