Analysis of YAP1 Gene as a Potential Immune-Related Biomarker and Its Relationship with the TAZ Expression

Background: YAP1 is a transcription factor closely related to mechanical stress and participates in the Hippo signal pathway. However, the prognostic functions and clinical significance of YAP1 in many cancers are unknown. In this study, by using bioinformatics from public databases, we purpose to comprehend its expression profile, prognostic value, immune infiltration pattern, and biological function. Methods: In this research, the Kaplan–Meier survival estimate and Mantel–Cox test indicated that YAP1 expression predicted prognosis. Using CIBERSORT and TIMER showed the components of the immune microenvironment. YAP1 pathways were then identified with Gene Set Enrichment Analysis (GSEA). Additionally, we analyzed YAP1 and TAZ potential Protein-Protein Interaction (PPI) by using GEO, STRING, and CYTOSCAPE databases. Results: Diverse cancers express YAP1 heterogeneously and it is genetically regulated. YAP1 was enrichment in pathways associated with immunity, metabolism, cancer, cell apoptosis, and cytoskeleton in various malignant cancers. Especially, YAP1 and TAZ analysis showed that immunity, metabolism, and cytoskeleton were highly enrichment pathways. Conclusions: These discoveries feature that YAP1 assumes a significant part in many kinds of cancers and establish the framework for an in-depth investigation into the function of YAP1 and TAZ.