This entry explores the complex discourse of gender reassignment, examining the varying perspectives from biological, social, and Islamic viewpoints. The discussion encompasses the reassignment from the initial binary gender concept to the nonbinary spectrum, challenging traditional understandings of gender. It addresses the contestation surrounding gender reassignment, including the initial concept of gender, the permissibility of medical intervention, and its implications, contributing to the debate from an Islamic perspective, primarily the Sunni approach, utilizing the principles of Islamic jurisprudence as a framework.