Chlordecone

Kepone, occasionally referred to as chlordecone, a synthetic chlorinated organic compound, made its first appearance in 1958. This chemical’s main application was as a pesticide, and it also treated fungal infections on bananas, non-bearing citrus trees, tobacco, and in lawns and flowers. As a result of occupational toxicity induced by being exposed to this industrial chemicals, the product was withdrawn from the market in the year 1975. The most prominent signs of chlordecone poisoning are tremors and an inability to control one’s excitability. These symptoms are brought on by a shift in the levels of neurotransmitters known as dopaminergic, serotonergic, and noradrenergic systems. It is extremely improbable that chlordecone may cause cancer if it is taken orally. The molecule will enter the liver once it has completed its journey through the digestive system, which is where it will undergo concentration. Chlordecone alcohol and glucuronide conjugates are the primary metabolites that are produced. In spite of the fact that chlordecone does not degrade naturally, the data imply that its breakdown occurs in a steady and methodical fashion. The chemical has been listed as persistent organic pollutants (POPs) under Annex A in 2009 in Stockholm Convention, and India also banned its manufacture, uses, export, and import in 2018. The environmental fate, persistency, toxicity, and health related issues have been discussed in this chapter in detail.