Finite Element Analysis of Myocardial Work in Cardiomyopathy

Analysis of myocardial work is essential in determination of left ventricle ejection fraction (LVEF) and non-invasive assessment of different types of cardiomyopathies. Two major classifications of cardiomyopathy are: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Although there are clinical improvements in cardiomyopathy risk assessment, patients are still under high risk of severe events. Computational modelling and computer-aided drug design can significantly advance the understanding of cardiac muscle activity in HCM and DCM, speed up the drug discovery and reduce the risk of severe events, aiming to improve the treatment of cardiomyopathy. This study is devoted to modelling of HCM using coupled macro and micro simulation through finite element (FE) modelling of fluid-structure interaction (FSI) and molecular drug interaction with the cardiac cells. FSI is used for modelling the HCM with nonlinear material model for heart wall. Analysis of myocardial work and changes of pressure and volume within the LV parametric model of HCM are presented at basic condition and after simulated effects of administered drugs. The obtained results provide better insight into the myocardial work of HCM patients as well as in estimated effects of drug therapy, leading to improved patient monitoring and treatment.