Assessment and Correlation of Morphometric and Tractographic Measures of Patients Diagnosed with Schizophrenia
摘要
This study describes the detection of anatomical changes in brain regions based on morphometric measures and white matter tracts in patients diagnosed with schizophrenia (F20.0 according to ICD-10) compared to a health control group. All data were checked for normality, and significant differences between the health control group and schizophrenia patients divided into groups based on symptomatic severity were tested for the investigated parameters. A correlation analysis was also performed between connectivity strength of brain regions and morphometric parameters. Based on these findings, three tracts were identified as possible biomarkers for this disorder: Paracentral lobule left—Paracentral lobule right; Supplementary motor area left—Anterior cingulate left; Thalamus left—Inferior temporal left.