Holocaust studies have increasingly taken a global perspective, framing the Holocaust as a phenomenon that transcended the borders of European nation-states and even the continent itself. The forced flight of Jewish refugees under Nazism set off a centrifugal movement that extended across five continents, including Latin America. Moreover, a rapidly expanding field of research examines the Holocaust’s resonances outside Europe, particularly in terms of memory. This book highlights the significant benefits of studying the Holocaust from a Latin American perspective. First, it underscores the necessity of understanding the Jewish refugee crisis during Nazism through the lens of the diverse regional responses it elicited. Second, it integrates the Holocaust into Latin American historiography, challenging the tendency to view it solely as a European event disconnected from the region’s history. Third, it provides valuable insights into the Holocaust’s non-European legacies, exploring how processes of settlement and memory-building have unfolded in geographical and socio-cultural contexts beyond Europe. Finally, the book places the refugees at the forefront, not only examining the impact of government immigration and integration policies, along with the decisions made by local Jewish community leaders, but also highlighting how the refugees themselves articulated their expectations, navigated their journeys, made choices, and preserved the memories of their past experiences.