Disadvantaged workers are those who face various forms of discrimination, exclusion, or vulnerability in the workforce, such as women, young people, immigrants, refugees, informal workers, LGBT (lesbian, gay, bisexual, and transgender) workers, low-profile workers, disabled workers, and elderly workers. Their limited access to social security, education, protection, and representation makes them more vulnerable to job dangers, diseases, accidents, and fatalities than other workers. In promoting a preventative culture and protecting proactive impoverished workers, the paper highlights the role that several stakeholders (including state authorities, employers, trade unions, NGOs, and international organizations) play. Publications and reports from international organizations, such as the European Commission (EC), the World Health Organization (WHO), the International Labor Organization (ILO), the United Nations (UN), and the European Agency for Safety and Health at Work. Defective laws and practices were discovered. Each of the eight underprivileged worker groups’ job risks, health consequences, and policy context were examined, and remedies were offered. The literature review technique was used to conduct the investigation.