Use of Ozonized Oil in Chronic Wounds of Lower Limbs: Preliminary Results

A randomized, double-blind clinical trial approved by the Research Ethics Committee (no. 4,246,236) was conducted in which elected patients had chronic wounds in the lower extremities. Participants aged 55 to 70 years, of both genders, with wounds on the lower limbs for more than 12 weeks of vascular, diabetic or traumatic etiology. 08 patients were randomly assigned in two groups: Group 1 – patients with chronic wounds received treatment with ozonated sunflower oil, concentration of 600 m2/kg; (milliequivalent/kg) and Group 2 – patients with chronic wounds who underwent treatment with traditional sunflower oil. All patients, when necessary, before starting treatment received debridement necrotic tissues was performed. To perform the bandage, the wound was first cleaned with 0.9% saline solution and then ozonized or traditional sunflower oil were administered throughout the wound bed, and then covered with sterile dry gauze, padding in bandage, and fixed with adhesive. All patients received the same procedure three times a week for 12 weeks. The results showed that the wounds of group 1, ozonized sunflower oil, improve in the aspects of the wounds with the presence of granulation tissue and absence of signs of infection and occurred reduction or complete repair of wounds. In the conventional curative group, with non-ozonized traditional sunflower oil, one wound completely repaired, however the other lesions continued with seroso type exudation, with the presence of edema at the wound site, presence of sign and signs of infection. In view of the above, it was observed that the use of ozonized sunflower oil promoted bactericidal and restorative effects.