Optimization of Design and Manufacturing Parameters of One-Plane Bevel Tipped 3D Printed Microneedles

This paper presents the micro needle’s fabrication process with a single-plane beveled needle tip (MNTB1). Sixteen microneedles were measured at four different angles ( \(-45^\circ \) ,0 \(^\circ \) ,45 \(^\circ \) ,90 \(^\circ \) ) to determine that and compared with the theoretical design values. This study shows the pre and post-printing process, where 0 \(^\circ \) was found to be the best printing angle, achieving dimensions in the geometry of the microneedle of 45,346 \(^\circ \) in experimental grade ( \(\theta \) ), 0,448 mm in length and 0,248 mm external diameter( \(\alpha \) ). On the other hand, excess resin is properly removed in the post-printing process when the microneedles are exposed to 10 min in 99% isopropyl alcohol. Then the microneedles are subjected to a curing process at 60 \(^\circ \) C for 30 min. Finally, the microneedles are subjected to a drilling process to enhance the 0,100 mm inner diameter. This fabrication process of a microneedle by 3D printing shows good results for implementation in a transdermal drug delivery device.