Comparative Evaluation of Efficacy of Antibiotics Incorporated Platelet Rich Fibrin Versus Platelet Rich Fibrin Alone in the Treatment of Intrabony Defects

Background:Platelet rich fibrin (PRF) is regarded as second generation platelet concentrate which is widely used to treat intraosseous defects. Bacterial contamination in periodontal regeneration is prevented by systemic antibiotics which may give rise to drug resistance and other side effects. Aim: The study aimed to explore clinical and radiographic effectiveness of amoxicillin incorporated PRF in the management of intrabony defects. Methods: Sixteen intrabony defects were treated with either Amoxicillin incorporated PRF (test site) or PRF alone (control site). Clinical parameters such as probing pocket depth (PPD), relative attachment level (RAL) and relative gingival margin level (RGML) were recorded at baseline and 6 months post-operatively. Wound healing index (WHI) was assessed at 7 and 14 days post-operatively. The defect fill at baseline and 6 months was calculated using cone beam computed tomography (CBCT). Results: On intergroup comparison of mean PPD, RAL and RGML showed no statistically significant difference. Comparison of WHI between control group and test group showed significant healing at 7 days post-operatively. Defect fill change showed no significant difference between control and test groups from baseline to 6 months. Conclusion: Both the groups seem to be effective in the treatment of intrabony defects. Initial wound healing was better in test group. However, randomized controlled trials with larger sample size are required to evaluate the efficacy of amoxicillin incorporated PRF in periodontal regeneration.