Breast Cancer

The benefit of post-lumpectomy and post-mastectomy radiation therapy (RT) in improving local control and overall survival has been demonstrated through multiple randomized trials. The classic fractionation scheme was typically 25 fractions (2 Gy/fraction) to the whole breast or chest wall with an additional RT boost to the lumpectomy cavity or mastectomy scar. However, multiple randomized studies have subsequently explored hypofractionated whole-breast RT in specific populations. There are also emerging data supporting the use of hypofractionated post-mastectomy RT. These alternative approaches to conventional whole-breast and post-mastectomy RT are viable options in certain patient populations.