Multifractal Analysis of Brain Tumor Interface in Glioblastoma

The dynamics of tumor growth is a very complex process, generally accompanied by numerous chromosomal aberrations that determine its genetic and dynamical heterogeneity. Consequently, the tumor interface exhibits a non-regular and heterogeneous behavior often described by a single fractal dimension. A more suitable approach is to consider the tumor interface as a multifractal object that can be described by a set of generalized fractal dimensions. In the present work, detrended fluctuation and multifractal analysis are used to characterize the complexity of glioblastoma.