Natural Biomolecules, Plant Extracts and Molecular Hydrogen—New Antioxidant Alternatives in the Management of Male Infertility

Oxidative stress resulting from an imbalance between the levels of reactive oxygen species (ROS) and antioxidants, plays a pivotal role in the pathophysiology of male sub- or infertility. Substantial evidence highlights the importance of oral antioxidant therapy in the management of male reproductive dysfunction. Nevertheless, studies focused on traditional antioxidant supplement have often come to inconclusive or contradictory results. In the meantime, scientific focus has shifted to alternative remedies such as plant extracts, plant-based biomolecules as well as molecular hydrogen which present with numerous health benefits and powerful antioxidant properties. As such, the focus of this chapter is to present recent evidence assessing the in vivo effects of alternative antioxidant remedies on the structural, functional, and oxidative indicators of male reproductive function with a special emphasis on rats as attractive animal models.