Mindfulness-based interventions are used worldwide both with healthy individuals and in clinical settings. These interventions commonly start with paying attention to bodily feelings such as one’s breathing. Interoception, that is the perception of signals originating inside the body, lives at the very interface of the mind and body as an essential link between the brain and the body’s physiology. It encompasses top-down and bottom-up psychological, neurological, and biochemical processes, which can – to a limited degree – become the object of attention, enter conscious sensory awareness, and provide guidance for self-regulatory behavior. Several self-report measures have been created to capture any changes in interoceptive capacities that may be associated with mindfulness-based interventions and other mind-body interventions. One such measure is the Multidimensional Assessment of Interoceptive Awareness (MAIA). The original MAIA contained 32 items on eight scales capturing related but independent dimensions of interoceptive attention, appraisal, and self-regulation. It has been translated into numerous languages and was revised into the 37-item MAIA-2. This chapter describes the development of the MAIA and subsequent MAIA-2, current knowledge of the measures’ psychometric properties, and a summary of the application, reliability, and validity of these measures for mindfulness-based interventions.