Metal-Organic Framework Composite-Based Biosensors: Biomedical Applications

Metal-organic frameworks (MOFs) are a novel type of crystalline material that boasts a range of uses across fields such as catalysis, biomedical engineering, microporous conductors, separation, and electrochemical biosensors. Thanks to their stability, tunable compositions and structures, and high porosity, MOFs are an excellent choice for crafting a diverse array of biosensors. Their unique properties, including strong fluorescence, chemical functionality, and affinity for probes such as DNA, aptamers, or antibodies, make them promising materials for use as biosensor platforms or electrode materials. These properties enable MOFs to detect biomedical analytes selectively and sensitively. Through coupling with different techniques such as electrochemical, fluorescence, and colorimetric methods, MOF-based materials showed promising applications for detecting various analytes. Regardless of their applications in the biomedical field, MOF-based biosensors are expected to pave the way for biochemical and food safety monitoring. Beyond that, this comprehensive chapter provides new insights into the construction of biosensors with MOF-based materials for biomedical applications.