Combating Prosthetic Infections: Synthesis, Characterization, and Evaluation of Magnesium-Doped Hydroxyapatite Nanofibers with Antibacterial Properties

Hydroxyapatite (HAp) is one of the most important in the family of calcium phosphates since it is an inorganic component of bone and it has been proven to be a biocompatible, osteoconductive, and osteoinductive material. However, it presents low antimicrobial activity making it susceptible to infections. This work aimed first to synthesize and characterize HAp nanofibers doped with Mg nanoparticles with a growth-oriented crystalline structure and second to evaluate their antimicrobial activity. For this, we synthesized HAp nanofibers by microwave-assisted hydrothermal method and carried out the structural characterization using the X-ray powder diffraction method. The morphological, topological, and microstructural characterization was performedwith scanning electron microscopy. Given the results, synthetic Mg-HAp nanofibers exhibited a hexagonal morphology and high purity and crystallinity. In addition, the nanofunctionality show of Mg-HAp exhibits good antimicrobial activity.