Magnetic Induction Spectroscopy for DNA Quantification: Preliminary Results

Biosensors on the basis of label-free and non-functionalization principles have been studied in the last decade. In particular, sensors for total Deoxyribonucleic Acid (DNA) and Genes, a necessary technology within molecular biology assays, have so far represented a major technological challenge. The objective of this study was to explore Magnetic Induction Spectroscopy (MIS) for DNA detection. The inductive phase measurements were obtained for five different DNA concentrations (1:1, 1:2, 1:4, 1:8 and 1:16), and analyzed to identify its potential value as a non-invasive tool for DNA quantification. According to the results, integration of the inductive phase curve in the frequency range of 1 to 10 MHz correlates with statistical significance to DNA concentration (R = 0.9723, P < 0.05). Sensitivity analysis for such integrated parameter seems pertinent for calibration of Magnetic Induction Spectroscopy measurements to estimate DNA concentrations. Further studies are warranted to confirm the observations.