POISE

This chapter describes the development of a piece of software for on-the-fly optimisation of NMR experimental parameters, titled POISE (Parameter Optimisation by Iterative Spectral Evaluation). POISE is primarily written in Python 3 and includes an interface to Bruker’s TopSpin software, allowing optimisations to be started directly from the TopSpin command line. Through this optimisation process, NMR acquisition parameters can be adjusted for individual spectrometers and samples, ultimately leading to improved spectral quality.