Pure Shift NMR

Pure shift NMR refers to the technique of acquiring broadband homodecoupled NMR spectra, where all multiplet structure is suppressed and each chemical environment gives rise to a singlet [1, 2]. Here, ‘broadband’ means that the couplings are removed from the entire spectrum, and ‘homodecoupled’ refers to the removal of homonuclear couplings: unlike heteronuclear couplings, these cannot be removed by applying RF pulses during the acquisition period, as that will destroy the desired signal itself.