A Theoretical Model for EEG Interpretation

How systems can be functionally integrated is of particular interest in neurosciences, while explaining the underlying bioelectrical phenomena of consciousness. Recent reviews have proposed the cross frequency phase-amplitude coupling (CfM) as a way by which the local brain activities (at high frequency) are integrated in large functional brain networks (by low frequency). Large brain networks are needed for consciousness and for strong cognitive tasks as well as they may be disrupted in pathological conditions as schizophrenia or emotional dysregulation. We have made a math model of high-frequency wave activities (by 9 dipoles) integrated by low-frequency modulators. In this model, “integration” is intended as phase coherence and activity inter correlation between dipoles. The highest integration was found to be linked to specific combination of modulation waves and dipole frequencies and phase differences. These results lead to the hypothesis that integrating the brain networks is not only necessary a low-frequency modulation in the Delta/Theta band, but also a predisposition of dipoles getting an harmonic resonance with that waves; this interpretation highlights the possibility that brain integration needs the past presence of harmonic resonance between dipoles and modulators, in relation with the personal history of parental functioning and neural development.