Investigation of the Glucose Molar Absorptivity Concerning Sugar Concentration from Visible to Mid-Infrared (450 – 1550 nm)

Constantly checking one’s blood glucose level is essential to managing diabetes and its complications. Non-invasive blood glucose monitoring approaches have been the subject of several investigations. However, there is currently no widely utilized commercial monitoring equipment. The optical-based approach for measuring blood glucose has great promise using a spectrum of visible and infrared wavelengths. Due to decreased absorption by the main components in tissue, light with a wavelength between 450 and 2500 nm may enter the skin with low-energy radiation. Fluctuations in light intensity due to absorption or scattering of glucose molecules, which depend on glucose concentration, may be utilized to determine the blood glucose level. This study examines the glucose molar absorptivity concerning sugar concentration in various solutions (aqueous solution, calibration solution, and whole blood) at wavelengths of 465 nm, 600 nm, 635 nm, 670 nm, 850 nm, 940 nm, 950 nm, 1300 nm, and 1550 nm. As a result, when the concentration of glucose in the glucose solution increased from 0 to 3000 mg/dL, the molar absorbance of the wavelengths 465 nm, 600 nm, 635 nm, 670 nm, 850 nm, 940 nm, 950 nm, 1300 nm, 1550 nm there was a marked change in each concentration. These values provide a means to accurately model spectra and a key for identifying and characterizing non-invasive measurements in complex matrices. This study's result can help develop the non-invasive optical-based glucose measurement method using near-infrared light in the future.