Solid Dispersion for Enhancing Bioactive Effectiveness of Resveratrol: A Mini Review

Resveratrol, a compound in the class of polyphenol, is broadly recognized for its magnificent antioxidant, anti-inflammatory, anti-coagulation, and manipulation of apoptosis properties. Despite its potential, the low solubility, instability, and poor bioavailability limit the therapeutic effectiveness of this bioactive agent in treatments. Solid dispersion has been perceived as a significant accomplishment in addressing these challenges with several commercially successful products. Many studies, therefore, focused on this approach to enhance the physicochemical characteristics of resveratrol. This review provides a comprehensive view of resveratrol-loaded solid dispersion according to its four distinct generations that have been developed over the decades, their formulations, preparation methods and achievements. Besides, future perspectives and remarkable points are also discussed in the article.