Evolutionary Aspects of Chamber Formation and Septation
摘要
The formed hearts of vertebrates are widely different in anatomy and performance, yet their embryonic hearts are surprisingly similar. Developmental and molecular biology are making great advances in reconciling these differences by revealing an evolutionarily conserved building plan to the vertebrate heart. This suggests that perspectives from evolution may improve our understanding of the formation of the human heart. Here, we exemplify this approach by discussing atrial and ventricular septationVentricularseptation and the associated processes of remodeling of the atrioventricular junctionAtrioventricularjunction and formation of the atrioventricular insulating plane.