Mantle Cell Lymphoma

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发表日期：

2024年

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Ben-Niklas Baermann,
Sascha Dietrich

摘要

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma, which is characterized by the chromosomal translocation t(11;14)(q13;q32) and overexpression of cyclin D1 in the vast majority of cases. Most patients present with advanced stage disease often with extra-nodal dissemination. High Ki67 proliferation index (Hoster et al. 2016), blastoid histologic variant (Bernard et al. 2001), and TP53 mutations represent high-risk features at diagnosis (Eskelund et al. 2017).