Systemic Light Chain Amyloidosis
摘要
Systemic light chain (AL) amyloidosis is a rare protein misfolding and deposition disorder. Clonal plasma cells or rarely B cells produce immunoglobulin light chains with the potential to misfold. Treatment is clone directed with the goal to achieve a complete or at least very good hematological remission. AutoHCT is an option in a selected group of patients. Results from cellular therapies are encouraging and will play an important role in the future.