Overweight and Obese Patients

Overweight and obesity are associated with physiological changes that can influence the pharmacokinetics of drugs. This has consequences for the dosage of drugs. Currently, for example, there are international recommendations for antibiotics and chemotherapies (with the exception of high-dose regimens) for dosing in overweight and obese patients. Unfortunately, data for conditioning regimens prior to hematopoietic stem cell tranplantation in terms of pharmacokinetic and/or clinical data is still quite limited. Therefore, future studies should focus on the pharmacokinetics and pharmacodynamics of specific conditioning regimens while more consistent and biologically relevant definitions of obesity should be utilized.