Non-CF Bronchiectasis

Bronchiectasis is a disease of recurrent wet cough and acute respiratory exacerbations with objective confirmation by abnormal bronchial dilatation on chest computed tomography scans. There is strong evidence that macrolide maintenance therapy reduces the frequency of respiratory exacerbations in both children and adults. This chapter will focus on the clinical use of macrolides in bronchiectasis in both adults and children, in relation to current guidelines, evidence and key recommendations, as well as exploring risks of long-term therapy and future research priorities.