Macrolide Use in Preschool-Aged Children with Acute or Recurrent Respiratory Tract Illnesses with Wheezing

Acute and recurrent lower respiratory tract illnesses with wheezing (WLRI) are a common problem among preschoolers and have high societal costs. Currently there are few options that are effective for either preventing or treating WLRI, especially in children without atopy. Macrolides may be a promising option for treating WLRI in preschool children, but there has been conflicting data on their efficacy. Their effect in WLRI may be due to their immunomodulatory or antimicrobial properties.