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Stroke Pharmacogenetics

  • Lauren E. Walker,
  • Anna Stewart,
  • Sir Munir Pirmohamed,
  • James F. Meschia,
  • Frances Bartlett Kinne

摘要

There are numerous clinical risk factors associated with stroke, including atrial fibrillation, hypertension, and hypercholesterolemia. Such risks can be ameliorated with appropriate pharmacotherapy. However, there is variability in response to drugs used for these conditions, which may, at least in part, be genetically determined. For instance, genetic determinants of response to warfarin, statins, antiplatelet agents, and some antihypertensives have been described.