Children with life-limiting conditions (LLCs) and other disabilities often present challenges which are complex for both families and health professionals. The increasing global estimate of children with LLCs means that there must be a greater and nuanced understanding of associated symptoms and their management to allow for a greater quality of life. This entry delves further into common symptoms seen in children with LLCs, management strategies both pharmacological and non-pharmacological, forms of psychosocial support to humanize the experience, advanced care planning, and ethical dimensions to consider.