The home setting is a crucial environment for students, serving as a foundation for academic engagement, relaxation, and daily activities. However, for students with disabilities, homes that lack accessibility can exacerbate psychological stress, leading to frustration, social disconnection, and diminished mental health. This entry explores the impact of home modifications, such as structural changes, smart technology, and adaptive designs, in alleviating these issues. By utilizing global data, the entry highlights the prevalence of disabilities among students and the psychological ramifications of inaccessible environments, which include higher rates of mental health challenges compared to their nondisabled peers. Key modifications, such as ramps, customizable lighting, artificial intelligence-enabled devices, and designs that consider sensory needs, are analyzed in this entry for their potential to enhance independence, safety, and academic performance. This entry underscores the need for policy advocacy, inclusive design approaches, and further research to verify the lasting mental health benefits of these interventions. By addressing environmental barriers, home modifications offer a vital strategy for fostering resilience, promoting equity, and enhancing the quality of life for students with disabilities.