Palliative care aims to identify and alleviate suffering for individuals with serious illness across the trajectory of illness, from diagnosis through death and family bereavement. While disability is not the same as illness, a person with a disability can experience serious illness. Disability can pre-date or co-occur with a serious illness diagnosis, arise because of treatment, or be unrelated. There are unique considerations for clinicians, families, and communities in providing palliative care for individuals with disabilities. Increasing attention is also being given to systemic and structural needs for advancing timely, appropriate, high-quality palliative care for individuals with disabilities who have a serious illness.