Home-based care for individuals with disabilities is a transformative approach that allows them to live with dignity, autonomy, and integration into their communities while receiving essential support in the comfort of their homes. This model is grounded in the social model of disability and aligns with the United Nations Convention on the Rights of Persons with Disabilities. It challenges traditional institutional care by promoting individual autonomy and social inclusion. By following the principles of person-centered care, home-based care provides tailored interventions that respect individual preferences and empower decision-making. Additionally, it incorporates the World Health Organization’s International Classification of Functioning, Disability, and Health framework, recognizing the multifaceted nature of disability. This approach integrates personal capabilities with environmental adaptations to enhance functioning and participation. Home-based care encompasses a wide range of services, from personal and medical care to psychosocial support and adaptive technologies, all delivered in a person-centered manner that empowers individuals. As global health systems transition from institutional care to community-based alternatives, home-based care stands out as a sustainable, inclusive, and cost-effective solution. This entry will explore the scope, models, benefits, challenges, and future directions of home-based care for persons with disabilities, drawing on global practices and policy frameworks to highlight best practices and identify opportunities for reform.