Vision disability affects over 285 million people worldwide and has profound implications not only for those with impaired sight but also for their caregivers and families. This entry examines the multifaceted impact of vision loss on familial relationships, caregiver burden, and the psychosocial well-being of all involved. This entry reviews the spectrum of vision disabilities from low vision to legal blindness and their common etiologies, emphasizing age-related macular degeneration, diabetic retinopathy, glaucoma, and congenital causes. Next, this entry explores how vision loss disrupts daily activities, independence, and social participation, precipitating emotional distress, role changes, and financial strain. Caregivers, spouses, adult children, or professional aides often assume new responsibilities for transportation, personal care, and household management, which can lead to caregiver fatigue, depression, and social isolation. Families similarly experience shifts in communication patterns and power dynamics, as decision-making may become centralized and children take on quasi-parental roles. This entry also discusses evidence-based strategies to support both patients and caregivers. Low-vision rehabilitation, including magnification devices, orientation and mobility training, and home environmental modifications, can restore autonomy and reduce caregiver load. Psychosocial interventions—peer support groups, family counseling, and caregiver respite services—ameliorate stress and foster resilience. Finally, this entry highlights the role of multidisciplinary teams (ophthalmologists, occupational therapists, social workers, and psychologists) in delivering comprehensive care, advocating for policy initiatives that improve access to low-vision services and caregiver support. By addressing the interconnected needs of individuals with vision disability and their families, this entry provides a roadmap for holistic interventions that enhance quality of life and sustain caregiving partnerships.