Emergency departments (EDs) are often the first point of contact for individuals with disabilities who experience acute health crises. Patients with disabilities face unique challenges in the ED, including physical, psychological, and behavioral barriers that require tailored care strategies. This entry provides an overview of the complexities in managing these patients, focusing on psychological distress, communication barriers, and the need for behavioral interventions. It explores effective communication strategies with patients with physical disabilities, the role of psychological assessment in emergency care, and the importance of personalized behavioral interventions to ensure a supportive environment. Additionally, this entry emphasizes the need for comprehensive training for emergency healthcare teams to foster disability-inclusive care, and the ethical and legal considerations involved in ensuring accessibility, autonomy, and dignity for patients with disabilities. This entry aims to inform and guide emergency healthcare professionals in delivering high-quality, compassionate care to individuals with disabilities in acute care settings.