The existing approach in health highlights the importance of combining biological, psychological, and social factors to understand the mechanisms associated with the onset, adaptation, and outcomes of diseases. The area of research that has become increasingly important is the relationship between personality and physical health. Although the complexity of the interactions between the varied factors involved does not allow for conclusive answers, robust evidence confirms that personality plays a fundamental role along the entire continuum of health. In this entry we review the existing evidence, suggesting the importance of further research within a lifespan, dimensional, and evolutionary perspective on personality.