Aurora kinase A (AURKA) is a critical regulator of mitosis and mitochondrial dynamics, and its dysregulation plays a significant role in the progression and therapeutic resistance of breast cancer. This chapter delves into the dual functions of AURKA, focusing on its impact on cell cycle regulation and mitochondrial reprogramming in cancer cells. In addition to its well-established role in mitosis, AURKA’s involvement in mitochondrial dynamics influences cancer metabolism and survival, particularly under stress conditions such as nutrient deprivation and low oxygen environments. While these findings offer promising therapeutic avenues, this chapter also emphasizes the need to consider the intersection of cancer and disability. Breast cancer treatments, including AURKA inhibitors, often induce disabilities such as fatigue, cognitive dysfunction, and mobility impairments. We explore how AURKA-targeted therapies could be adapted to improve treatment outcomes for individuals with pre-existing disabilities or those facing treatment-induced impairments. Through a multidisciplinary approach, we highlight the importance of integrating oncology and disability research to enhance the quality of life for cancer patients. The chapter concludes by proposing future research directions that aim to better understand AURKA’s role in cancer-related disabilities and develop more personalized, accessible therapies that address both oncological and functional challenges.