The COVID-19 pandemic has profoundly affected population mental health globally, with people living with psychosis facing unique challenges. This entry examines the direct and indirect consequences of the COVID-19 pandemic on people living with psychotic disorders, highlighting increased morbidity and mortality associated with COVID-19 infection. It also explores how pandemic-related stressors have influenced and exacerbated psychotic symptoms and disrupted mental healthcare service pathways, revealing significant barriers to vaccination and access to mental healthcare. Additionally, the entry addresses the broader implications for clinical practice and public health policy, emphasizing the need for tailored interventions to support this vulnerable population and their caregivers in navigating the complexities introduced by the pandemic. Understanding these dynamics is crucial for improving outcomes for patients with psychosis and their caregivers in the context of ongoing public health crises.