Brain tumors are among the most challenging cancers to treat, often necessitating surgical resection as a primary approach to management. While advances in surgical techniques have improved survival rates, the procedure frequently results in a range of physical, cognitive, and emotional disabilities that significantly impact patients’ quality of life. Physical impairments, such as motor deficits, sensory loss, and coordination issues, commonly arise due to the complex anatomy of the brain and the infiltrative nature of tumors. Cognitive deficits, including memory loss, attention difficulties, language impairments, and executive function challenges, further compound the recovery process, creating barriers to independence and social reintegration. These disabilities also place a substantial emotional and psychological burden on both patients and caregivers, requiring comprehensive support systems to address these challenges effectively. Rehabilitation strategies, including physical therapy, cognitive rehabilitation, and speech therapy, are essential for mitigating these deficits and enhancing functional recovery. Recent innovations, such as robotic-assisted rehabilitation, virtual reality-based therapies, and noninvasive brain stimulation, have shown promise in accelerating recovery and leveraging the brain’s neuroplasticity to rebuild damaged neural pathways. Multidisciplinary care, involving collaboration among healthcare providers, family members, and community resources, is crucial for addressing the interconnected physical, cognitive, and emotional aspects of recovery. Advances in surgical techniques, such as awake craniotomy and fluorescence-guided tumor resection, along with emerging research in neuroplasticity and artificial intelligence, are paving the way for improved outcomes and a more personalized approach to care. This entry highlights the multifaceted challenges faced by brain tumor patients postsurgery and emphasizes the importance of comprehensive, patient-centered care in overcoming these hurdles. By integrating cutting-edge research, innovative therapies, and robust support systems, the future holds promise for enhancing recovery and improving the quality of life for individuals living with disabilities following brain tumor treatment.