This entry examines the many issues faced by those diagnosed with both cancer and disability. This entry provides a comprehensive analysis of the intersection between cancer treatment and disability management, including the medical, psychological, social, and legal factors involved in concurrently treating dual diseases. This entry addresses the occurrence and effect of dual diagnoses, modifications in cancer treatment protocols for individuals with disabilities, and the integration of support systems and services. It further examines psychological impacts, coping mechanisms, and the duties of caregivers. Case studies exemplify these themes via specific instances of obstacles and successes, while novel therapies, research initiatives, and policy modifications provide progressive viewpoints for discourse. This entry aims to enhance awareness and support for persons with dual illnesses by pushing for holistic and empathetic strategies that cater to both their physical and cognitive requirements. Moreover, actionable information for healthcare practitioners, patients, families, and the wider healthcare community fosters a comprehensive approach.